Specificity of Interferon

Specificity of interferon action in protein synthesis.

Inhibitors of elongation steps in protein synthesis such as cycloheximide and anisomycin mimic interferon treatment in that they specifically inhibit the synthesis of certain viral proteins. These specific effects are seen only at very low concentrations of the antibiotics, under conditions where host cellular protein synthesis, as well as cell viability, are not severely reduced. A qualitative...

Immunological specificity of Staphylococal penicillinase

Surface antigens of melanoma and melanocytes. Specificity of induction of Ia antigens by human gamma-interferon

IFN-gamma is known to induce expression of Ia antigens on a variety of cell types. In the present study, this activity of IFN-gamma has been analyzed with a panel of 36 melanoma cell lines, normal melanocytes, and 97 cell lines representing a range of other differentiation lineages. 55% of the melanoma cell lines express Ia antigens in a constitutive manner without IFN-gamma induction. Of the 1...

STUDIES ON THE TISSUE SPECIFICITY OF COLONY STIMULATING FACTOR

In this study granulocyte-macrophage colony stimulating factor (CSF) was prepared from rabbit and guinea pig lung tissues. The biological activity of these CSFs was measured on semisolid agar culture and compared with those of mouse and rat. Weight of animals, incubation time and cross-reactivity of CSFs with different bone marrow sources were also investigated. The results showed that both...

The specificity of interferon-gamma-based blood tests in the identification of latent tuberculosis infection.

I do not agree with this tentative conclusion as the study by LEE et al. [2] does not report the true specificity of the two tests, as the control group of 15and 16-yr-old students used to examine the specificity of the assays, although healthy, had a defined risk of existing tuberculosis (TB) infection. This was acknowledged by LEE et al. [2] in the discussion section of their study as follows.